Immune thrombocytopenia (ITP) is a heterogeneous disorder with variable clinical symptoms. Health Related Quality of Life (HRQoL) could be considered in ITP, as in numerous chronic diseases, as a method to provide information about the effects of medical interventions. Restoring and/or maintaining quality of life should be an important goal of treatment. This multicenter study using SF-36 and ITP-PAQ questionnaires to assess the HRQoL in patients with ITP in the real world, will determine the influencing factors of HRQoL so as to provide a sufficient basis for clinical decision making.